[Psychomotor retardation associated to depression differs from that of normal aging].

Sylvie Bonin-Guillaume, Thierry Hasbroucq, Olivier Blin
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引用次数: 11

Abstract

Psychomotor retardation (PMR) is a main symptom of depressive illness. In the elderly, it is associated with the severity of depression and poor prognosis. However, PMR is also commonly associated with normal aging, Therefore, depressive PMR is frequently misinterpreted as the age-related slowing in the elderly, which contributes to poor recognition of depression. Moreover, neurobiological and neuroanatomical studies on PMR hardly allowed to discriminate geriatric depression from normal aging. Reaction time experiments have rarely been tested in elderly population although they are particularly suited for examining PMR. We performed two reaction time experiments using an additive factor analysis in healthy and depressed old individuals with the hypothesis that PMR associated to depression differed from that of normal aging. Results showed that age-related PMR affected all stages of central nervous system information processing, while PMR associated with depression is limited to the components of response-selection and motor-adjustment. These results clearly show that PMR in geriatric depression differed from the age related slowing. Depression also spares stimulus preprocessing in old individuals as it did in younger adults.

[与抑郁症相关的精神运动迟缓不同于正常衰老]。
精神运动障碍(PMR)是抑郁症的主要症状。在老年人中,它与抑郁症的严重程度和预后不良有关。然而,PMR通常也与正常的衰老有关,因此,抑郁症PMR经常被误解为老年人与年龄相关的减缓,这导致了对抑郁症的认识不足。此外,PMR的神经生物学和神经解剖学研究很难将老年抑郁症与正常衰老区分开来。反应时间实验很少在老年人中进行测试,尽管它们特别适合于检查PMR。我们对健康和抑郁的老年人进行了两个反应时间实验,并假设抑郁相关的PMR与正常衰老不同。结果表明,年龄相关的PMR影响中枢神经系统信息加工的所有阶段,而与抑郁相关的PMR仅限于反应选择和运动调节成分。这些结果清楚地表明,老年抑郁症的PMR不同于年龄相关的减缓。抑郁症在老年人中也不需要刺激预处理,就像在年轻人中一样。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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