Sensing, presenting, and regulating PAMPs.

J L de Diego, G Gerold, A Zychlinsky
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Abstract

Recognition of microbial infection and initiation of immune responses are controlled by multiple mechanisms. Toll-like receptors (TLRs) are key components of the innate immune system that detect microbial infection. TLR activation helps to eliminate the invading pathogens, coordinate systemic defenses, and initiate adaptive immune responses. Despite progress elucidating the TLR signaling aspects and the physiological relevance of TLRs in microbial infections, the molecular basis of microbial recognition by TLRs is still not fully understood. In this article we focus on the availability of microbial ligands to regulate presentation to TLRs and assist in our understanding of TLR-mediated microbial recognition.

感知、呈现和调节PAMPs。
微生物感染的识别和免疫应答的启动由多种机制控制。toll样受体(TLRs)是先天免疫系统检测微生物感染的关键组成部分。激活TLR有助于消除入侵的病原体,协调系统防御,并启动适应性免疫反应。尽管在阐明TLR信号方面和TLR在微生物感染中的生理相关性方面取得了进展,但TLR对微生物识别的分子基础仍未完全了解。在这篇文章中,我们将重点关注微生物配体的可用性,以调节tlr的呈递,并帮助我们理解tlr介导的微生物识别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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