Edgars Abele, Kira Rubina, Ramona Abele, Olegs Dzenitis, Pavel Arsenyan, Juris Popelis, Maris Veveris, Dainuvite Meirena, Edmunds Lukevics
{"title":"Silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents.","authors":"Edgars Abele, Kira Rubina, Ramona Abele, Olegs Dzenitis, Pavel Arsenyan, Juris Popelis, Maris Veveris, Dainuvite Meirena, Edmunds Lukevics","doi":"10.1155/MBD.2002.307","DOIUrl":null,"url":null,"abstract":"<p><p>Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 6","pages":"307-13"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.307","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metal-Based Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/MBD.2002.307","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
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