Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils.

Ling Li, Zhiqiang Shen, Weimin Yang, Wanling Wu, Weiping Liu, Zhihe Chen
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引用次数: 3

Abstract

The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(-1)) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.

二聚体铜(II)双(o-乙酰氧基苯甲酸酯)对沙鼠缺血再灌注损伤的脑保护作用。
研究了阿斯匹林铜[二聚体铜(II)双(o-乙酰氧基苯甲酸酯)]对沙鼠全脑缺血10min后再灌注60min的脑保护作用。结果表明,灌胃阿斯匹酸铜(7.5、15.0和30.0 mg Kg(-1))能显著促进缺血再灌注损伤大鼠脑电图波幅的恢复,减轻皮层过氧化脂含量的增加和超氧化物歧化酶活性的降低。提示阿斯匹林铜具有潜在的神经保护作用,其机制可能与提高内源性超氧化物歧化酶活性有关。
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