Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association?

Abstract

A case of multiple malignancies in a 41 year old African American man is described. After surgical excision and radiotherapy of dermatofibrosarcoma protuberans, the patient developed small bowel adenocarcinoma. We propose a common etiology to these canceres via tumor suppressor gene p53.