Role of tight junctions in cell proliferation and cancer

Q Medicine

Progress in Histochemistry and Cytochemistry Pub Date : 2007-06-15 DOI:10.1016/j.proghi.2007.01.001

Lorenza González-Mariscal, Susana Lechuga , Erika Garay

引用次数: 129

Abstract

The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/β-catenin complex in adherens junctions during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer.

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紧密连接在细胞增殖和癌症中的作用

上皮细胞获得癌变表型涉及细胞间粘连的破坏。E-cadherin/β-catenin复合物在细胞转化过程中粘附连接中的重组已被广泛认识。相反，在这个过程中紧密连接(TJs)的含义开始被解开。本文就TJ蛋白在细胞增殖和肿瘤中的作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Histochemistry and Cytochemistry 生物-细胞生物学

CiteScore

4.67

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.