A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis.

International journal of gastrointestinal cancer Pub Date : 2005-01-01 DOI:10.1385/IJGC:36:2:99

Hiroya Takeuchi, Ken Futamata, Arafumi Maeshima, Shigemichi Hirose, Atsushi Shimada, Yoshiki Kawaguchi, Jo Tokuyama, Koji Osumi, Shinya Kishi, Takashi Hojo, Shiei Kim, Norihito Wada, Takashi Oishi, Yoh Isobe, Shunji Ikeuchi, Kiyoshi Kubochi, Sumio Matsumoto

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引用次数: 3

Abstract

We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.

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原发性胃小细胞癌伴罕见淋巴结转移1例。

我们报告一例罕见的原发性胃小细胞癌(GSCC)合并胃小管腺癌。一名60多岁的男性在胃中央有一个隆起的肿瘤和溃疡。病人接受了远端胃切除术和淋巴结清扫。病理检查显示两个分离的胃病变，包含原发性GSCC和原发性胃管腺癌的成分。免疫组化(IHC)检查显示小细胞癌的肿瘤细胞突触素、嗜铬粒蛋白A和神经细胞粘附分子(NCAM)阳性。GSCC细胞和腺癌细胞独立转移到每个区域淋巴结。进一步研究单个肿瘤的生物学行为可能有助于开发新的GSCC治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of gastrointestinal cancer

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