Palladium-catalyzed intramolecular annulation of difluoroalkenes to difluoro- and trifluoromethylated indane analogs

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.1016/j.jfluchem.2023.110115

Yongxi Li , Guangwu Sun , Xihang He , Honggui Lv , Bing Gao

引用次数: 0

Abstract

An intramolecular annulation strategy has been developed for the synthesis of fluoroalkylated indane-type analogs. The difluoromethyl and trifluoromethyl functional motifs could be derived from gem-difluoroalkenes through this palladium-catalyzed reaction. This method is also extendable to other fluoroalkenes and multi-component reactions.

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钯催化的二氟烯烃分子内环化成二氟和三氟甲基化茚类似物

一种分子内环化策略已被开发用于合成氟烷基化茚类类似物。通过钯催化反应，可以从宝石二氟烯烃中得到二氟甲基和三氟甲基功能基序。该方法也可扩展到其它含氟烯烃和多组分反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.