The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response.

Journal of studies on alcohol Pub Date : 2006-09-01 DOI:10.15288/jsa.2006.67.700

Kathleen T Brady, Angela E Waldrop, Aimee L McRae, Sudie E Back, Michael E Saladin, Himanshu P Upadhyaya, Raymond F Anton, Patrick K Randall

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引用次数: 52

Abstract

Objective: Posttraumatic stress disorder (PTSD) is commonly comorbid with alcohol-use disorders. Abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis response are common in both disorders. The objective of this study was to investigate HPA axis reactivity to the cold pressor task (CPT) among individuals with alcohol dependence, PTSD, and comorbid alcohol dependence and PTSD.

Method: Participants were 119 individuals with alcohol dependence only (n = 31), comorbid alcohol dependence and PTSD (n = 28), PTSD without alcohol dependence (n = 30), and a control group (n = 30). Subjective response, adrenal corticotropic hormone (ACTH), and cortisol were measured before, immediately after, and for 120 minutes after each subject completed the CPT.

Results: There were significant group and gender differences found in the subjective and ACTH response, with significantly higher subjective stress ratings and decreased ACTH response in the alcohol-dependent, PTSD, and comorbid alcohol dependent-PTSD groups compared with the control group.

Conclusions: There were differences in the HPA axis and subjective response to the CPT between the control group and both the alcohol and PTSD groups. The HPA response in the comorbid alcohol-PTSD group was not significantly different than that of the alcohol-only or PTSD-only groups.

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酒精依赖和创伤后应激障碍对冷压力任务反应的影响。

目的:创伤后应激障碍(PTSD)通常与酒精使用障碍合并症。下丘脑-垂体-肾上腺(HPA)轴反应异常在两种疾病中都很常见。本研究的目的是探讨酒精依赖、创伤后应激障碍以及酒精依赖和创伤后应激障碍共病患者的下丘脑轴对冷压任务(CPT)的反应性。方法:119名酒精依赖者(n = 31)，酒精依赖合并PTSD (n = 28)， PTSD合并酒精依赖者(n = 30)和对照组(n = 30)。主观反应、促肾上腺皮质激素(ACTH)和皮质醇分别在每位受试者完成CPT之前、之后和完成后120分钟进行测量。结果:在主观和ACTH反应方面存在显著的组和性别差异，与对照组相比，酒精依赖组、PTSD组和合并酒精依赖-PTSD组的主观压力评分明显较高，ACTH反应明显降低。结论:酒精组和创伤后应激障碍组与对照组的HPA轴和对CPT的主观反应存在差异。酒精- ptsd共病组的HPA反应与单纯酒精组或单纯ptsd组无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of studies on alcohol

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