The reliability and validity of the Alcohol Use Disorders Identification Test (AUDIT) in a German general practice population sample.

Inga Dybek, Gallus Bischof, Janina Grothues, Susa Reinhardt, Christian Meyer, Ulfert Hapke, Ulrich John, Andreas Broocks, Fritz Hohagen, Hans-Jürgen Rumpf
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引用次数: 144

Abstract

Objective: Our goal was to analyze the retest reliability and validity of the Alcohol Use Disorders Identification Test (AUDIT) in a primary-care setting and recommend a cut-off value for the different alcohol-related diagnoses.

Method: Participants recruited from general practices (GPs) in two northern German cities received the AUDIT, which was embedded in a health-risk questionnaire. In total, 10,803 screenings were conducted. The retest reliability was tested on a subsample of 99 patients, with an intertest interval of 30 days. Sensitivity and specificity at a number of different cut-off values were estimated for the sample of alcohol consumers (n=8237). For this study, 1109 screen-positive patients received a diagnostic interview. Individuals who scored less than five points in the AUDIT and also tested negative in a second alcohol-related screen were defined as "negative" (n=6003). This definition was supported by diagnostic interviews of 99 screen-negative patients from which no false negatives could be detected. As the gold standard for detection of an alcohol-use disorder (AUD), we used the Munich-Composite International Diagnostic Interview (MCIDI), which is based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria.

Results: On the item level, the reliability, measured by the intraclass correlation coefficient (ICC), ranged between .39 (Item 9) and .98 (Item 10). For the total score, the ICC was .95. For cut-off values of eight points and five points, 87.5% and 88.9%, respectively, of the AUDIT-positives, and 98.9% and 95.1%, respectively, of the AUDIT-negatives were identically identified at retest, with kappa = .86 and kappa = .81. At the cut-off value of five points, we determined good combinations of sensitivity and specificity for the following diagnoses: alcohol dependence (sensitivity and specificity of .97 and .88, respectively), AUD (.97 and .92), and AUD and/or at-risk consumption (.97 and .91).

Conclusions: Embedded in a health-risk questionnaire in primary-care settings, the AUDIT is a reliable and valid screening instrument to identify at-risk drinkers and patients with an AUD. Our findings strongly suggest a lowering of the recommended cut-off value of eight points.

酒精使用障碍鉴定试验(审核)在德国全科人群样本中的信度和效度。
目的:我们的目的是分析初级保健机构中酒精使用障碍鉴定试验(AUDIT)的重测信度和效度,并推荐不同酒精相关诊断的临界值。方法:从德国北部两个城市的全科医生(gp)招募的参与者接受了审计,该审计嵌入到健康风险问卷中。总共进行了10,803次筛查。重测信度在99例患者的亚样本中进行测试,测息间隔为30天。对酒精消费者样本(n=8237)在若干不同临界值下的敏感性和特异性进行了估计。在这项研究中,1109名筛查阳性的患者接受了诊断性访谈。在审计中得分低于5分且在第二次酒精相关筛查中检测为阴性的个人被定义为“阴性”(n=6003)。这一定义得到了对99名筛查阴性患者的诊断性访谈的支持,其中没有发现假阴性。作为检测酒精使用障碍(AUD)的金标准,我们使用了慕尼黑复合国际诊断访谈(MCIDI),该访谈基于精神障碍诊断和统计手册第四版的标准。结果:在项目水平上,用类内相关系数(ICC)测量的信度范围在0.39(项目9)和0.98(项目10)之间。总得分为0.95。对于8点和5点的临界值,重新检测时审计阳性分别为87.5%和88.9%,审计阴性分别为98.9%和95.1%,kappa = .86和kappa = .81。在截断值为5点时,我们确定了以下诊断的敏感性和特异性的良好组合:酒精依赖(敏感性和特异性分别为0.97和0.88),AUD(。97和。92),澳元和/或有风险的消费(。97和0.91)。结论:在初级保健机构的健康风险问卷中,审计是一种可靠和有效的筛查工具,可以识别有风险的饮酒者和AUD患者。我们的研究结果强烈建议将推荐的临界值降低8个点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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