{"title":"Liquid incubator with perfluorochemicals for extremely premature infants.","authors":"Takehiko Hiroma, Atsushi Baba, Masanori Tamura, Tomohiko Nakamura","doi":"10.1159/000092529","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Maintenance of appropriate body temperature, humidification and prevention of skin injury are very important in the management of extremely premature infants with immature skin. We have developed a new closed liquid incubator, utilising the characteristics of perfluorochemical (PFC) liquids, i.e., high specific gravity and chemical and biological inertness. The potential of this incubator to control body temperature was evaluated in rats.</p><p><strong>Methods: </strong>PFC liquid (FC43; 3M Company, Tokyo, Japan) within the incubator was heated or cooled and the rectal temperature of each rat and the PFC temperature were monitored.</p><p><strong>Results: </strong>The rectal temperature of rats floating on the PFC liquid surface changed almost in parallel to the temperature of PFC within the incubator, indicating that this technique can be used to warm or cool adults rats in a stable manner. The relative humidity of air within the incubator was maintained constant at 100%.</p><p><strong>Conclusions: </strong>The liquid incubator used in the present study maintained an environment with a relative humidity of 100% and allowed stable maintenance of temperature in adult rats. We also demonstrated that heating and cooling the PFC liquid allowed control of body temperature. Although further studies are required, this new incubator may be useful for the clinical management of extremely premature infants.</p>","PeriodicalId":9091,"journal":{"name":"Biology of the neonate","volume":"90 3","pages":"162-7"},"PeriodicalIF":0.0000,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000092529","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology of the neonate","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000092529","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2006/4/3 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Objectives: Maintenance of appropriate body temperature, humidification and prevention of skin injury are very important in the management of extremely premature infants with immature skin. We have developed a new closed liquid incubator, utilising the characteristics of perfluorochemical (PFC) liquids, i.e., high specific gravity and chemical and biological inertness. The potential of this incubator to control body temperature was evaluated in rats.
Methods: PFC liquid (FC43; 3M Company, Tokyo, Japan) within the incubator was heated or cooled and the rectal temperature of each rat and the PFC temperature were monitored.
Results: The rectal temperature of rats floating on the PFC liquid surface changed almost in parallel to the temperature of PFC within the incubator, indicating that this technique can be used to warm or cool adults rats in a stable manner. The relative humidity of air within the incubator was maintained constant at 100%.
Conclusions: The liquid incubator used in the present study maintained an environment with a relative humidity of 100% and allowed stable maintenance of temperature in adult rats. We also demonstrated that heating and cooling the PFC liquid allowed control of body temperature. Although further studies are required, this new incubator may be useful for the clinical management of extremely premature infants.
目的:维持适当的体温，湿润和防止皮肤损伤是处理皮肤不成熟的极早产儿非常重要的。我们开发了一种新的封闭式液体培养箱，利用全氟化学(PFC)液体的特点，即高比重和化学和生物惰性。在大鼠身上评价了该培养箱控制体温的潜力。方法:PFC液(FC43;3M Company, Tokyo, Japan)在培养箱内加热或冷却，监测每只大鼠的直肠温度和PFC温度。结果:浮在PFC液体表面的大鼠直肠温度变化与培养箱内PFC温度变化几乎平行，表明该技术可以稳定地用于成年大鼠的温或冷。恒温箱内空气相对湿度保持100%恒定。结论:本研究使用的液体培养箱保持了一个相对湿度为100%的环境，并且可以稳定地维持成年大鼠的温度。我们还证明了加热和冷却PFC液体可以控制体温。虽然需要进一步的研究，但这种新的培养箱可能对极早产儿的临床管理有用。
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