Consistent expression of HGF and c-met in the perinatal lung.

Biology of the neonate Pub Date : 2006-01-01 Epub Date: 2006-02-22 DOI:10.1159/000091663

P Lassus, J Janer, C Haglund, R Karikoski, L C Andersson, S Andersson

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引用次数: 12

Abstract

Background: Hepatocyte growth factor (HGF), an epithelial cell mitogen, has been shown to participate in normal lung development and in regeneration after lung injury. In human preterm infants, lower pulmonary HGF has been associated with more severe respiratory disease.

Objectives: We studied the protein expression of HGF and its receptor c-met during the perinatal period in the human lung.

Methods: Immunohistochemistry for HGF and c-met was performed on lung tissues from autopsies of 4 fetuses, 5 preterm infants, 5 term infants, and 4 infants with bronchopulmonary dysplasia.

Results: Immunohistochemistry for HGF showed staining in all cases in mesenchymal cells (fibroblasts and cartilage cells). Additional staining was found in bronchial and distal airway epithelium. Immunohistochemistry for c-met showed staining in bronchial and distal airway epithelium, and in most cases in neutrophils.

Conclusions: The consistent expression of HGF and c-met during the perinatal period supports a physiological role for HGF in human lung development.

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围产期肺中HGF和c-met的一致表达。

背景:肝细胞生长因子(HGF)是一种上皮细胞有丝分裂原，已被证明参与正常肺发育和肺损伤后的再生。在人类早产儿中，较低的肺HGF与更严重的呼吸系统疾病有关。目的:研究围产期人肺组织中HGF及其受体c-met的蛋白表达。方法:对4例胎儿、5例早产儿、5例足月儿和4例支气管肺发育不良患儿的肺组织进行HGF和c-met的免疫组化检测。结果:所有病例间充质细胞(成纤维细胞和软骨细胞)免疫组化均显示HGF染色。支气管和远端气道上皮也有染色。c-met免疫组织化学染色显示支气管和远端气道上皮，大多数中性粒细胞染色。结论:围产期HGF和c-met的一致表达支持了HGF在人肺发育中的生理作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biology of the neonate

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