Objective biophysical findings in patients with sensitive skin.

A V Roussaki-Schulze, E Zafiriou, D Nikoulis, E Klimi, E Rallis, E Zintzaras
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Abstract

The term sensitive skin has been used to describe a clinical phenomenon of hyperreactivity of the human skin, which develops exaggerated reactions when exposed to external factors. The aim of this study was to determine objective biophysical findings in patients with sensitive skin compared to those individuals with nonsensitive skin. Thirty-two patients with sensitive skin and 30 healthy volunteers with nonsensitive skin were studied. The testing methods included in vivo and in vitro tests: epicutaneous testing (Patch tests); measurement of sebum and hydration of the skin; alkali resistance test; stinging test with lactic acid; reaction to aqueous solution of methyl nicotinate 0.5%, 1.4% and acetyl-b-methylcholine chloride 1:1000; pH measurement; dermographism; and measurement of total and specific IgE. Significant results were observed in the measurement of sebum (p < 0.01) and hydration (p < 0.05) of the skin, in the alkali resistance test (p < 0.05), in the vascular reaction to methyl nicotinate (p < 0.01) and to acetyl-b-methylcholine chloride (p < 0.01) and in the skin response to allergens of the European standard (p < 0.01) and cosmetic series (p < 0.05). In addition, the subjective findings of stinging test produced significant results (p < 0.001) as was anticipated. Patients with sensitive skin possess very dry skin with low fatness, which leads to a disturbance of the protective skin barrier function. They also present a hyperreaction of the skin blood vessels, increased transcutaneous penetration of water-soluble chemicals, enhanced immune responsiveness, significant decrease of alkali resistance and a heightened neurosensory stimulation.

目的敏感性皮肤患者的生物物理表现。
“敏感皮肤”一词已被用来描述人类皮肤的一种临床现象,即当暴露于外部因素时,皮肤会产生夸张的反应。本研究的目的是确定敏感皮肤患者与非敏感皮肤患者的客观生物物理结果。研究对象为32例皮肤敏感患者和30例皮肤非敏感的健康志愿者。试验方法包括体内和体外试验:表皮试验(贴片试验);测量皮肤的皮脂和水分;耐碱试验;乳酸刺痛试验;与烟酸甲酯0.5%、1.4%和乙酰-b-甲基氯化胆碱1:1000水溶液的反应;pH值测量;皮肤划痕现象;以及总IgE和特异性IgE的测定。皮肤皮脂测定(p < 0.01)、水合作用测定(p < 0.05)、抗碱试验(p < 0.05)、血管对烟酸甲酯反应(p < 0.01)、乙酰-b-甲基胆碱氯反应(p < 0.01)、皮肤对欧洲标准过敏原反应(p < 0.01)和化妆品系列过敏原反应(p < 0.05)均有显著性结果。此外,刺痛试验的主观结果如预期的那样产生了显著的结果(p < 0.001)。敏感皮肤患者皮肤非常干燥,脂肪含量低,导致皮肤保护屏障功能紊乱。它们还表现为皮肤血管的过度反应,水溶性化学物质经皮渗透增加,免疫反应增强,抗碱能力显著降低,神经感觉刺激增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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