[Effects of benazepril combined with valsartan on congestive heart failure].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Pub Date : 2005-11-01

Jian-feng Ye, Dong-sheng Liu

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Abstract

Objective: To observe the effects of routine doses of benazepril combined with valsartan on congestive heart failure.

Methods: Totally 203 patients with congestive heart failure were randomized into Group A (receiving benazepril 20 mg/day), Group B (benazepril,10 mg/day plus valsartan, 80 mg/day), and group C (valsartan 160 mg/day) for different treatment protocols on the basis of routine therapy for heart failure with digitalis, diuretics and beta blockers. The cardiac functions and echocardiographical findings were evaluated before and after the treatments.

Results: All the patients showed improvement of NYHA class, left ventricular end-diastolic dimension (LVEDd), left ventricular end-systolic dimension (LVESd) and left ventricular ejection fraction (LVEF) (P<0.01), and the effect was better in group B than in group A (P>0.05), and both groups A and B had better results than group C (P<0.05). No serious adverse effects were found.

Conclusion: The combination of benazepril and valsartan at routine doses can be effective for treating congestive heart failure.

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[苯那普利联合缬沙坦治疗充血性心力衰竭的疗效]。

目的:观察常规剂量苯那普利联合缬沙坦治疗充血性心力衰竭的疗效。方法:203例充血性心力衰竭患者在洋地黄、利尿剂和受体阻滞剂治疗心力衰竭的基础上，随机分为A组(贝那普利20 mg/d)、B组(贝那普利10 mg/d +缬沙坦80 mg/d)和C组(缬沙坦160 mg/d)，采用不同的治疗方案。观察治疗前后心功能及超声心动图表现。结果:所有患者NYHA评分、左室舒张末尺寸(LVEDd)、左室收缩末尺寸(LVESd)、左室射血分数(LVEF)均有改善(P0.05)，且A、B组均优于C组(P0.05)。结论:常规剂量贝那普利联合缬沙坦治疗充血性心力衰竭疗效显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

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