Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2021-01-20 eCollection Date: 2021-01-01 DOI:10.5812/ijem.104889

Shahin Yarahmadi, Nasrin Azhang, Mahmood Salesi, Khaled Rahmani

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Abstract

Background: Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation.

Objective: This study aimed to identify familial-related risk factors for CH in Iranian newborns.

Methods: A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor.

Results: Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother's hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%).

Conclusions: This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone.

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伊朗新生儿先天性甲状腺功能减退的家族相关风险:一项基于人群的病例对照研究

背景:先天性甲状腺功能减退症(CH)是一种最常见的内分泌疾病，是一种可预防的智力低下原因。目的:本研究旨在确定伊朗新生儿CH的家族相关危险因素。方法:在伊朗CH患者的国家登记系统中进行了一项基于人群的病例对照研究。在这项研究中，906名对照组和454名病例进行了为期一年的研究。采用logistic回归模型调查家族相关因素。还计算了每个重要危险因素的人口归因分数(PAF)。结果:通过多因素分析，观察到先天性异常(优势比(OR): 5.77, 95%可信区间(CI): 2.37 - 14.01)、家族精神发育迟滞史(OR:2.10, 95% CI: 1.15-3.83)、孕期母亲甲状腺功能减退(OR: 2.01, 95% CI: 1.33 - 3.03)、家族内婚姻(OR:1.49, 95% CI: 1.18 - 1.89)、妊娠期糖尿病(OR: 1.69, 95% CI: 1.09 - 2.63)、家族中有甲状腺功能减退的孩子(OR: 2.48, 95% CI: 2.48)的患者发生CH的风险增加。1.39 - 4.42)，双胞胎或更多(or: 2.61, 95% CI: 1.31 - 5.21)。家庭相关危险因素中PAF最高的是家庭内婚姻(14.9%)。结论:本研究揭示家族相关危险因素和近亲婚姻在伊朗CH高发中起重要作用。在伊朗，大约15%的CH可以仅仅归因于家庭内部婚姻。

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来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.