{"title":"Effects of betaine on non-alcoholic liver disease.","authors":"Weiqiang Chen, Minjuan Xu, Minwen Xu, Yucai Wang, Qingyan Zou, Shuixiang Xie, Liefeng Wang","doi":"10.1017/S0954422421000056","DOIUrl":null,"url":null,"abstract":"<p><p>The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) poses a growing challenge in terms of its prevention and treatment. The 'multiple hits' hypothesis of multiple insults, such as dietary fat intake, <i>de novo</i> lipogenesis, insulin resistance, oxidative stress, mitochondrial dysfunction, gut dysbiosis and hepatic inflammation, can provide a more accurate explanation of the pathogenesis of NAFLD. Betaine plays important roles in regulating the genes associated with NAFLD through anti-inflammatory effects, increased free fatty oxidation, anti-lipogenic effects and improved insulin resistance and mitochondrial function; however, the mechanism of betaine remains elusive.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0954422421000056","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0954422421000056","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/4/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 6
Abstract
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) poses a growing challenge in terms of its prevention and treatment. The 'multiple hits' hypothesis of multiple insults, such as dietary fat intake, de novo lipogenesis, insulin resistance, oxidative stress, mitochondrial dysfunction, gut dysbiosis and hepatic inflammation, can provide a more accurate explanation of the pathogenesis of NAFLD. Betaine plays important roles in regulating the genes associated with NAFLD through anti-inflammatory effects, increased free fatty oxidation, anti-lipogenic effects and improved insulin resistance and mitochondrial function; however, the mechanism of betaine remains elusive.
期刊介绍:
Nutrition Research Reviews offers a comprehensive overview of nutritional science today. By distilling the latest research and linking it to established practice, the journal consistently delivers the widest range of in-depth articles in the field of nutritional science. It presents up-to-date, critical reviews of key topics in nutrition science advancing new concepts and hypotheses that encourage the exchange of fundamental ideas on nutritional well-being in both humans and animals.