Frequency of Cytomegalovirus Viral Load in Iranian Human Immunodeficiency Virus-1-Infected Patients with CD4+ Counts <100 Cells/mm3.

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2021-01-01 Epub Date: 2021-03-31 DOI:10.1159/000514385

Mohammad Reza Jabbari, Hoorieh Soleimanjahi, Somayeh Shatizadeh Malekshahi, Mohammad Gholami, Leila Sadeghi, Minoo Mohraz

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引用次数: 3

Abstract

Objectives: The aim of present work was to assess cytomegalovirus (CMV) viremia in Iranian human immunodeficiency virus (HIV)-1-infected patients with a CD4+ count <100 cells/mm3 and to explore whether CMV DNA loads correlate with CD4+ cell counts or associated retinitis.

Methods: This study was conducted at the AIDS research center in Iran on HIV-1-infected patients with CD4+ count <100 cells/mm3, antiretroviral therapy-naive, aged ≥18 years with no previous history of CMV end-organ disease (CMV-EOD).

Results: Thirty-nine of 82 patients (47.56%) had detectable CMV viral load ranging from 66 to 485,500 IU/mL. CMV viral load in patients with retinitis ranges from 352 to 2,720 IU/mL, and it was undetectable in 2 patients. No significant associations between CMV viremia and CD4+ cell count was found (p value = 0.31), whereas significant association of CMV viremia in HIV-infected patients with retinitis was found (p < 0.02).

Conclusions: We estimated the frequency of CMV viral load infection in Iranian HIV-1-infected patients with a CD4+ cell count <100 mm3/mL in the largest national referral center for HIV-1 infection in Iran. Further research is required on the relevance of CMV viral load in diagnostic and prognostic value of CMV-EOD.

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CD4+计数<100细胞/mm3的伊朗人类免疫缺陷病毒1感染患者巨细胞病毒载量的频率

目的:本研究的目的是评估伊朗人类免疫缺陷病毒(HIV)-1感染患者CD4+计数的巨细胞病毒(CMV)病毒血症。方法:本研究在伊朗艾滋病研究中心对HIV-1感染患者的CD4+计数进行了研究。结果:82例患者中有39例(47.56%)可检测到CMV病毒载量，范围为66 ~ 485,500 IU/mL。视网膜炎患者的巨细胞病毒载量在352 ~ 2720 IU/mL之间，2例患者检测不到巨细胞病毒载量。CMV病毒血症与CD4+细胞计数无显著相关性(p值= 0.31)，而CMV病毒血症在hiv感染视网膜炎患者中有显著相关性(p < 0.02)。结论:我们估计了CD4+细胞计数的伊朗hiv -1感染患者巨细胞病毒载量感染的频率

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.