Preclinical cardiac disease in women and men with primary aldosteronism.

IF 1.8 4区医学

Blood Pressure Pub Date : 2021-08-01 Epub Date: 2021-03-30 DOI:10.1080/08037051.2021.1904775

Arleen Aune, Marina Kokorina, Marianne Aa Grytaas, Helga Midtbø, Kristian Løvås, Eva Gerdts

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引用次数: 5

Abstract

Abstract Purpose We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods Conventional and speckle tracking echocardiography was performed in 109 patients with PA and 89 controls with essential hypertension (EH). LV hypertrophy was identified if LV mass index exceeded 47.0 g/m2.7 in women and 50.0 g/m2.7 in men. LV systolic myocardial function was assessed by global longitudinal strain (GLS) and midwall shortening. Results PA patients had higher prevalence of LV hypertrophy (52 vs. 21%, p < 0.001) than EH patients in both sexes, while GLS did not differ by sex or hypertension aetiology. In multivariable analyses, presence of LV hypertrophy was associated with PA and obesity in both sexes, while lower systolic myocardial function, whether measured by GLS or midwall shortening, was not associated with PA, but primarily with higher body mass index and LV mass index, respectively, in both sexes (all p < 0.05). Conclusion Having PA was associated with higher prevalence of LV hypertrophy both in women and men, compared to EH. PA was not associated with LV systolic myocardial function in either sex.

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原发性醛固酮增多症患者的临床前心脏病

目的:我们检测原发性醛固酮增多症(PA)、左室肥厚和左室收缩心肌功能之间的性别特异性关联。材料与方法:对109例PA患者和89例对照组原发性高血压(EH)患者进行常规超声心动图和斑点跟踪超声心动图检查。如果女性左室质量指数超过47.0 g/m2.7，男性超过50.0 g/m2.7，则确定为左室肥大。采用总纵应变(GLS)和中壁缩短法评价左室收缩心肌功能。结果:肺动脉高压患者的左室肥厚发生率更高(52% vs. 21%， p)。结论:与EH相比，男性和女性的左室肥厚发生率都更高。无论男女，PA均与左室收缩心肌功能无关。

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来源期刊

Blood Pressure Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.20

自引率

5.60%

发文量

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.