Resistance Status of Bacteria from a Health Facility in Ghana: A Retrospective Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-03-04 eCollection Date: 2021-01-01 DOI:10.1155/2021/6648247

Abass Inusah, Elvis Quansah, Kwabena Fosu, Isaac Dadzie

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引用次数: 4

Abstract

Background: Regardless of the global concerted effort to control the development and spread of antimicrobial resistance, increasing cases are continually documented at many medical centres. This situation is reinforced by inadequate information on the trend of resistance resulting from lack of regular antimicrobial resistance surveillance. The present study sought to detect the number of multidrug-resistant (MDR), extended drug-resistant (XDR), and pandrug-resistant (PDR) bacterial isolates at a health facility in Ghana from January 2018 to July 2020.

Method: A total of 800 data on antimicrobial testing results were extracted from the records of the health facility. The extracted data were explored for the detection of MDR, XDR, and PDR. The study further determined the use of antibiotics using the multiple-drug resistance index (MDRI).

Results: Except for Staphylococcus and Neisseria spp., all bacterial isolates showed extremely high (100%) proportion of MDR. Although only Staphylococcus spp. (38 (4.8%)) was observed to be XDR, the rest of the bacteria showed the potential to attain the status of XDR or PDR. MDRI indicated high use of antibiotics in the health facility.

Conclusion: The high antimicrobial resistance observed by the study underscores the need for prompt and effective antibiotic resistance control strategies.

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加纳一家卫生机构细菌耐药性状况:回顾性研究

背景:尽管全球共同努力控制抗菌素耐药性的发展和传播，但在许多医疗中心记录的病例不断增加。由于缺乏定期的抗菌素耐药性监测，关于耐药性趋势的信息不足，加剧了这种情况。本研究旨在检测2018年1月至2020年7月在加纳一家卫生机构中分离出的耐多药(MDR)、扩展耐药(XDR)和泛耐药(PDR)细菌的数量。方法:从卫生机构的记录中提取共800份抗菌药物检测结果数据。提取的数据用于MDR、XDR和PDR的检测。该研究通过多重耐药指数(MDRI)进一步确定抗生素的使用情况。结果:除葡萄球菌和奈瑟菌外，所有菌株的耐多药比例均极高(100%)。虽然只有葡萄球菌(38株(4.8%))为XDR，但其余细菌均有可能达到XDR或PDR的状态。MDRI指出，卫生机构大量使用抗生素。结论:本研究观察到的高耐药性表明需要及时有效的抗生素耐药性控制策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.