Advances in Quantitative Analysis of ¹⁸F-Sodium Fluoride Coronary Imaging.

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular Imaging Pub Date : 2021-01-15 eCollection Date: 2021-01-01 DOI:10.1155/2021/8849429

Jacek Kwiecinski, Martin Lyngby Lassen, Piotr J Slomka

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引用次数: 6

Abstract

¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease. ¹⁸F-NaF uptake colocalizes to high-risk and ruptured atherosclerotic plaques. Most recently, ¹⁸F-NaF coronary uptake was shown to be a robust and independent predictor of myocardial infarction in patients with advanced coronary artery disease. In this review, we provide an overview of the advances in coronary ¹⁸F-NaF imaging. In particular, we discuss the recently developed and validated motion correction techniques which address heart contractions, tidal breathing, and patient repositioning during the prolonged PET acquisitions. Additionally, we discuss a novel quantification approach-the coronary microcalcification activity (which has been inspired by the widely employed method in oncology total active tumor volume measurement). This new method provides a single number encompassing ¹⁸F-NaF activity within the entire coronary vasculature rather than just information regarding a single area of most intense tracer uptake.

Abstract Image

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18f -氟化钠冠状动脉造影定量分析进展。

18f -氟化钠(18F-NaF)正电子发射断层扫描(PET)已成为一种有前途的无创成像工具，用于评估冠状动脉疾病的活动性钙化过程。18F-NaF摄取与高风险和破裂的动脉粥样硬化斑块共定位。最近，18F-NaF冠状动脉摄取被证明是晚期冠状动脉疾病患者心肌梗死的可靠且独立的预测因子。在这篇综述中，我们就冠状动脉18F-NaF成像的进展进行综述。特别地，我们讨论了最近开发和验证的运动矫正技术，解决心脏收缩，潮汐呼吸，以及在长时间PET采集期间患者重新定位。此外，我们讨论了一种新的量化方法-冠状动脉微钙化活动(这是受到广泛应用于肿瘤总活性肿瘤体积测量方法的启发)。这种新方法提供了包含整个冠状血管内18F-NaF活性的单一数字，而不仅仅是关于最强烈示踪剂摄取的单个区域的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

自引率

3.60%

发文量

期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.

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