Predictive Platforms of Bond Cleavage and Drug Release Kinetics for Macromolecule-Drug Conjugates.

IF 4.4 2区 化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Souvik Ghosal, Javon E Walker, Christopher A Alabi
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引用次数: 4

Abstract

Macromolecule-drug conjugates (MDCs) occupy a critical niche in modern pharmaceuticals that deals with the assembly and combination of a macromolecular carrier, a drug cargo, and a linker toward the creation of effective therapeutics. Macromolecular carriers such as synthetic biocompatible polymers and proteins are often exploited for their inherent ability to improve drug circulation, prevent off-target drug cytotoxicity, and widen the therapeutic index of drugs. One of the most significant challenges in MDC design involves tuning their drug release kinetics to achieve high spatiotemporal precision. This level of control requires a thorough qualitative and quantitative understanding of the bond cleavage event. In this review, we highlight specific research findings that emphasize the importance of establishing a precise structure-function relationship for MDCs that can be used to predict their bond cleavage and drug release kinetic parameters.

大分子-药物偶联物的键裂解和药物释放动力学预测平台。
大分子-药物偶联物(MDCs)在现代制药中占有重要地位,它处理大分子载体、药物货物和连接物的组装和组合,以创造有效的治疗方法。合成的生物相容性聚合物和蛋白质等大分子载体因其固有的改善药物循环、防止脱靶药物细胞毒性和扩大药物治疗指数的能力而经常被利用。MDC设计中最重要的挑战之一是调整其药物释放动力学以达到高时空精度。这种水平的控制需要对键解理事件进行彻底的定性和定量理解。在这篇综述中,我们重点介绍了一些特定的研究结果,这些研究结果强调了建立MDCs精确的结构-功能关系的重要性,该关系可用于预测它们的键裂解和药物释放动力学参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
6.00%
发文量
810
期刊介绍: ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.
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