Auditory cortex hyperconnectivity before rTMS is correlated with tinnitus improvement

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2023-09-01 DOI:10.1016/j.nrl.2021.01.007

E. Kim , H. Kang , T.-S. Noh , S.-H. Oh , M.-W. Suh

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引用次数: 1

Abstract

Introduction

Repetitive transcranial magnetic stimulation (rTMS) has been used as a potential treatment for tinnitus; however, its effectiveness is variable and unpredictable. We hypothesized that resting-state functional connectivity before rTMS may be correlated with rTMS treatment effectiveness.

Methods

We applied 1-Hz rTMS to the left primary auditory (A1) and dorsolateral prefrontal cortices (DLPFC) of 10 individuals with tinnitus and 10 age-matched controls. Resting-state functional magnetic resonance imaging (fMRI) studies were performed approximately one week before rTMS. Seed-based connectivity analyses were conducted for each individual, with seed regions as rTMS target areas.

Results

Compared to controls, the left superior temporal areas showed significantly increased positive connectivity with the left A1 and negative connectivity with the left DLPFC in the tinnitus group. The left frontoparietal and right cerebellar areas showed significantly increased negative connectivity with the left A1 and positive connectivity with the left DLPFC. Seed-based hyperconnectivity was correlated with tinnitus improvement (pre-rTMS vs. 2-week post-rTMS Tinnitus Handicap Inventory scores). Tinnitus improvement was significantly correlated with left A1 hyperconnectivity; however, no correlation was observed with left DLPFC connectivity. Positive rTMS outcomes were associated with significantly increased positive connectivity in bilateral superior temporal areas and significantly increased negative connectivity in bilateral frontal areas.

Conclusions

Our results suggest that oversynchronisation of left A1 connectivity before rTMS of the left A1 and DLPFC is associated with treatment effectiveness.

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rTMS前听觉皮层超连接性与耳鸣改善相关

重复性经颅磁刺激（rTMS）已被用作耳鸣的潜在治疗方法；然而，它的有效性是可变的和不可预测的。我们假设rTMS前的静息状态功能连接可能与rTMS的治疗效果相关。方法对10名耳鸣患者和10名年龄匹配的对照组的左初级听觉（A1）和背外侧前额叶皮层（DLPFC）进行1-Hz rTMS检测。静息状态功能性磁共振成像（fMRI）研究在rTMS前约一周进行。对每个个体进行基于种子的连接性分析，将种子区域作为rTMS目标区域。结果与对照组相比，耳鸣组左颞上区与左A1的正连接和与左DLPFC的负连接显著增加。左侧额顶和右侧小脑区域与左侧A1的负连接显著增加，与左侧DLPFC的正连接显著增加。基于种子的超连通性与耳鸣改善相关（rTMS前与rTMS后2周耳鸣障碍量表得分）。耳鸣改善与左侧A1超连通性显著相关；然而，未观察到与左侧DLPFC连接的相关性。rTMS阳性结果与双侧颞上区阳性连接显著增加和双侧额区阴性连接显著增加有关。结论我们的研究结果表明，在左A1和DLPFC的rTMS之前，左A1连接的过度同步与治疗效果有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.