Kai Huang, Shuyan Wen, Wenshuo Wang, Jing-E Zhou, Jiechun Huang, Fangrui Wang, Liewen Pang, Yiqing Wang, Xiaotian Sun
{"title":"Erythrocyte membrane coated nanoparticle-based control releasing hydrogen sulfide system protects ischemic myocardium.","authors":"Kai Huang, Shuyan Wen, Wenshuo Wang, Jing-E Zhou, Jiechun Huang, Fangrui Wang, Liewen Pang, Yiqing Wang, Xiaotian Sun","doi":"10.2217/nnm-2020-0404","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To construct a long circulatory and sustained releasing H<sub>2</sub>S system and explore its protective effects on myocardial ischemia and reperfusion (I/R) injury. <b>Materials & methods</b>: Red blood cell (RBC) membrane-coated, diallyl trisulfide (DATS)-carrying mesoporous iron oxide nanoparticles (MIONs) (RBC-DATS-MIONs) were prepared and characterized. Cytotoxicity and cellular uptake were studied <i>in vitro</i>, followed by <i>in vivo</i> assessment of safety, distribution and effect on cardiac function following I/R injury. <b>Results</b>: RBC-DATS-MIONs exhibited excellent biocompatibility, extended circulatory time and controlled-release of H<sub>2</sub>S in plasma and myocardium. They exhibited superior therapeutic effects on <i>in vitro</i> hypoxia/reoxygenation models and <i>in vivo</i> myocardial I/R models, which involved various mechanisms, including anti-apoptosis, anti-inflammatory and antioxidant activities. <b>Conclusion</b>: This work provides a new potential platform for best utilizing the protective effects of H<sub>2</sub>S by prolonging its releasing process.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/nnm-2020-0404","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/2/18 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Aim: To construct a long circulatory and sustained releasing H2S system and explore its protective effects on myocardial ischemia and reperfusion (I/R) injury. Materials & methods: Red blood cell (RBC) membrane-coated, diallyl trisulfide (DATS)-carrying mesoporous iron oxide nanoparticles (MIONs) (RBC-DATS-MIONs) were prepared and characterized. Cytotoxicity and cellular uptake were studied in vitro, followed by in vivo assessment of safety, distribution and effect on cardiac function following I/R injury. Results: RBC-DATS-MIONs exhibited excellent biocompatibility, extended circulatory time and controlled-release of H2S in plasma and myocardium. They exhibited superior therapeutic effects on in vitro hypoxia/reoxygenation models and in vivo myocardial I/R models, which involved various mechanisms, including anti-apoptosis, anti-inflammatory and antioxidant activities. Conclusion: This work provides a new potential platform for best utilizing the protective effects of H2S by prolonging its releasing process.