Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis

FEMS immunology and medical microbiology Pub Date : 2005-09-01 DOI:10.1016/j.femsim.2005.05.013

Maria Sueli S. Felipe , Fernando A.G. Torres , Andrea Q. Maranhão , Ildinete Silva-Pereira , Marcio J. Poças-Fonseca , Elida G. Campos , Lídia M.P. Moraes , Fabrício B.M. Arraes , Maria José A. Carvalho , Rosângela V. Andrade , André M. Nicola , Marcus M. Teixeira , Rosália S.A. Jesuíno , Maristela Pereira , Célia M.A. Soares , Marcelo M. Brígido

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引用次数: 28

Abstract

Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.

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人类致病真菌巴西副球虫的功能基因组

巴西副球孢子菌是一种二态和温度调节真菌，是副球孢子菌病的病原体，是一种广泛存在于拉丁美洲的地方病。致病性被认为是细胞分化过程的结果，这种真菌在人类感染期间经历了从菌丝到酵母细胞的过程。为了阐明这一过程中涉及的分子机制，巴西实验室网络对这两种细胞类型进行了转录组项目。本文通过对菌丝期和酵母期6022个与表达基因相关的类群的数据分析，对巴西芽孢霉二态化过程中的真菌代谢和分子适应进行了全面的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FEMS immunology and medical microbiology 医学-传染病学

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0.00%

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审稿时长

3-8 weeks