Maria Sueli S. Felipe , Fernando A.G. Torres , Andrea Q. Maranhão , Ildinete Silva-Pereira , Marcio J. Poças-Fonseca , Elida G. Campos , Lídia M.P. Moraes , Fabrício B.M. Arraes , Maria José A. Carvalho , Rosângela V. Andrade , André M. Nicola , Marcus M. Teixeira , Rosália S.A. Jesuíno , Maristela Pereira , Célia M.A. Soares , Marcelo M. Brígido
{"title":"Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis","authors":"Maria Sueli S. Felipe , Fernando A.G. Torres , Andrea Q. Maranhão , Ildinete Silva-Pereira , Marcio J. Poças-Fonseca , Elida G. Campos , Lídia M.P. Moraes , Fabrício B.M. Arraes , Maria José A. Carvalho , Rosângela V. Andrade , André M. Nicola , Marcus M. Teixeira , Rosália S.A. Jesuíno , Maristela Pereira , Célia M.A. Soares , Marcelo M. Brígido","doi":"10.1016/j.femsim.2005.05.013","DOIUrl":null,"url":null,"abstract":"<div><p><span><em>Paracoccidioides brasiliensis</em></span><span><span> is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis<span><span>, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from </span>mycelium to </span></span>yeast cells<span><span> during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome<span> project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during </span></span>dimorphism in </span></span><em>P. brasiliensis</em> from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.</p></div>","PeriodicalId":12220,"journal":{"name":"FEMS immunology and medical microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.femsim.2005.05.013","citationCount":"28","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEMS immunology and medical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S092882440500146X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 28
Abstract
Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.