Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever

FEMS immunology and medical microbiology Pub Date : 2005-04-01 DOI:10.1016/j.femsim.2004.11.012

Rong-Fu Chen , Jien-Wei Liu , Wen-Ting Yeh , Lin Wang , Jen-Chieh Chang , Hong-Ren Yu , Jiin-Tsuey Cheng , Kuender D. Yang

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引用次数: 78

Abstract

To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.

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登革出血热患者辅助性T - 1反应改变但病毒载量未增加

为了探讨登革出血热患者与非登革出血热患者是否存在不同的病毒载量、免疫介质或辅助性T (Th)反应，我们同时检测了台湾南部一次大规模登革出血热暴发中病毒载量、免疫介质和Th1/Th2转录因子T-bet/ gta3 mRNA的表达。结果显示，登革出血热患者与非登革出血热患者的病毒载量无显著差异。登革热患者IFN-γ水平较高，但登革出血热患者IL-10水平明显较高。进一步研究发现，登革出血热患者T-bet明显低于登革热患者，但两组外周血白细胞GATA-3 mRNA表达无显著差异。综上所述，T-bet mRNA表达降低与IL-10水平升高所反映的Th1反应改变可能参与了登革热出血热的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FEMS immunology and medical microbiology 医学-传染病学

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审稿时长

3-8 weeks

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