{"title":"The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle.","authors":"W Jonathan Ryves, Adrian J Harwood","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>GSK-3 is a multifunctional protein kinase known to play a pivotal role in the regulation of metabolism, the cytoskeleton and gene expression. It also interacts with the cell cycle in a number of ways. GSK-3 forms part of both Wnt and Hh signalling pathways and hence controls expression of a number of cell cycle regulatory genes. Prominent among these is cyclin D1. GSK-3 also phosphorylates cyclin D1 to promote its nuclear export and subsequent degradation. In this chapter we examine how GSK-3 mediates these effects and consider how therapeutic strategies may be developed to specifically target these pathways.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"489-95"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in cell cycle research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
GSK-3 is a multifunctional protein kinase known to play a pivotal role in the regulation of metabolism, the cytoskeleton and gene expression. It also interacts with the cell cycle in a number of ways. GSK-3 forms part of both Wnt and Hh signalling pathways and hence controls expression of a number of cell cycle regulatory genes. Prominent among these is cyclin D1. GSK-3 also phosphorylates cyclin D1 to promote its nuclear export and subsequent degradation. In this chapter we examine how GSK-3 mediates these effects and consider how therapeutic strategies may be developed to specifically target these pathways.