Cap-dependent translation and control of the cell cycle.

Progress in cell cycle research Pub Date : 2003-01-01
Patrick Cormier, Stéphane Pyronnet, Patrick Salaün, Odile Mulner-Lorillon, Nahum Sonenberg
{"title":"Cap-dependent translation and control of the cell cycle.","authors":"Patrick Cormier,&nbsp;Stéphane Pyronnet,&nbsp;Patrick Salaün,&nbsp;Odile Mulner-Lorillon,&nbsp;Nahum Sonenberg","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The control of gene expression at the translational level has emerged in the past decade as an important aspect of cell growth, proliferation and malignant transformation. Translation is primarily regulated at the initiation step, and mitogen-dependent signaling pathways converge to modulate the activity of translation initiation factors. In most tumors tested, at least one translation initiation factor is overexpressed and overexpression of translation initiation factors often provokes transformation. Malignant transformation could be caused by the increased translation of a subset of mRNAs encoding important proteins which are required for cell growth and proliferation. These mRNAs usually possess regulatory sequences that render their translation more sensitive to changes in the activity of translation initiation factors. In this chapter, we describe recent advances illustrating the importance of translation in cell cycle progression and cell transformation. Control of translation initiation may represent an excellent target for antitumor drugs.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"469-75"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in cell cycle research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The control of gene expression at the translational level has emerged in the past decade as an important aspect of cell growth, proliferation and malignant transformation. Translation is primarily regulated at the initiation step, and mitogen-dependent signaling pathways converge to modulate the activity of translation initiation factors. In most tumors tested, at least one translation initiation factor is overexpressed and overexpression of translation initiation factors often provokes transformation. Malignant transformation could be caused by the increased translation of a subset of mRNAs encoding important proteins which are required for cell growth and proliferation. These mRNAs usually possess regulatory sequences that render their translation more sensitive to changes in the activity of translation initiation factors. In this chapter, we describe recent advances illustrating the importance of translation in cell cycle progression and cell transformation. Control of translation initiation may represent an excellent target for antitumor drugs.

帽依赖的翻译和细胞周期的控制。
在翻译水平上对基因表达的控制是近十年来出现的,是细胞生长、增殖和恶性转化的一个重要方面。翻译主要在起始阶段受到调控,有丝分裂原依赖的信号通路聚集在一起调节翻译起始因子的活性。在大多数被检测的肿瘤中,至少有一种翻译起始因子过表达,而过表达的翻译起始因子通常会引发转化。恶性转化可能是由编码细胞生长和增殖所需的重要蛋白质的mrna亚群的翻译增加引起的。这些mrna通常具有调控序列,使其翻译对翻译起始因子活性的变化更加敏感。在本章中,我们描述了最近的进展,说明翻译在细胞周期进程和细胞转化中的重要性。控制翻译起始可能是抗肿瘤药物的一个很好的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信