Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology

IF 7.4 1区 物理与天体物理 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
O.V. Semyachkina-Glushkovskaya , S.G. Sokolovski , A. Goltsov , A.S. Gekaluyk , E.I. Saranceva , O.A. Bragina , V.V. Tuchin , E.U. Rafailov
{"title":"Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology","authors":"O.V. Semyachkina-Glushkovskaya ,&nbsp;S.G. Sokolovski ,&nbsp;A. Goltsov ,&nbsp;A.S. Gekaluyk ,&nbsp;E.I. Saranceva ,&nbsp;O.A. Bragina ,&nbsp;V.V. Tuchin ,&nbsp;E.U. Rafailov","doi":"10.1016/j.pquantelec.2017.05.001","DOIUrl":null,"url":null,"abstract":"<div><p>For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others. Recently application of lasers in biology and medicine presents itself as one of the emerging areas. In this review, we will outline the recent advances in using lasers for the generation of singlet oxygen, traditionally used to kill tumour cells or induce thrombotic stroke model due to damage vascular effects. Over the last two decade, completely new results on cerebrovascular effects of singlet oxygen generated during photodynamic therapy (PDT) have been shown alongside promising applications for delivery of drugs and nanoparticles<span><span><span> into the brain for therapy of brain cancer. Furthermore, a “gold key” has been found to overcome the limitations of PDT, such as low light penetration and high toxicity of photosensitizers, by direct generation of singlet oxygen using quantum-dot </span>laser diodes emitting in the </span>near infrared (NIR) spectral range. It is our motivation to highlight these pioneering results in this review, to improve understanding of the biological role of singlet oxygen and to provide new perspectives for improving clinical application of laser based therapy in further research.</span></p></div>","PeriodicalId":414,"journal":{"name":"Progress in Quantum Electronics","volume":null,"pages":null},"PeriodicalIF":7.4000,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pquantelec.2017.05.001","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Quantum Electronics","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079672717300149","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 16

Abstract

For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others. Recently application of lasers in biology and medicine presents itself as one of the emerging areas. In this review, we will outline the recent advances in using lasers for the generation of singlet oxygen, traditionally used to kill tumour cells or induce thrombotic stroke model due to damage vascular effects. Over the last two decade, completely new results on cerebrovascular effects of singlet oxygen generated during photodynamic therapy (PDT) have been shown alongside promising applications for delivery of drugs and nanoparticles into the brain for therapy of brain cancer. Furthermore, a “gold key” has been found to overcome the limitations of PDT, such as low light penetration and high toxicity of photosensitizers, by direct generation of singlet oxygen using quantum-dot laser diodes emitting in the near infrared (NIR) spectral range. It is our motivation to highlight these pioneering results in this review, to improve understanding of the biological role of singlet oxygen and to provide new perspectives for improving clinical application of laser based therapy in further research.

激光诱导单线态氧的产生及其在脑血管生理中的作用
55年来,激光技术已经从实验室研究扩展到广泛的领域,例如电信和数据存储等。近年来,激光在生物医学领域的应用已成为新兴领域之一。在这篇综述中,我们将概述利用激光产生单线态氧的最新进展,单线态氧传统上用于杀死肿瘤细胞或由于损伤血管效应而诱导血栓性中风模型。在过去的二十年中,光动力治疗(PDT)过程中产生的单线态氧对脑血管的影响的全新结果已被证明,同时也有希望将药物和纳米颗粒输送到脑癌治疗的大脑中。此外,利用近红外(NIR)光谱范围内发射的量子点激光二极管直接产生单线态氧,已经发现了克服PDT局限性的“金钥匙”,例如光敏剂的低光穿透性和高毒性。我们的动机是在本文中强调这些开创性的结果,以提高对单线态氧的生物学作用的认识,并为进一步研究提高激光治疗的临床应用提供新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Progress in Quantum Electronics
Progress in Quantum Electronics 工程技术-工程:电子与电气
CiteScore
18.50
自引率
0.00%
发文量
23
审稿时长
150 days
期刊介绍: Progress in Quantum Electronics, established in 1969, is an esteemed international review journal dedicated to sharing cutting-edge topics in quantum electronics and its applications. The journal disseminates papers covering theoretical and experimental aspects of contemporary research, including advances in physics, technology, and engineering relevant to quantum electronics. It also encourages interdisciplinary research, welcoming papers that contribute new knowledge in areas such as bio and nano-related work.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信