Conformational changes in corticotropin solutions

Abstract

The behaviour and physico-chemical characteristics of corticotropin, or adrenocorticotropic hormome (ACTH), in aqeous solution as a function of ionic strength and temperature have been studied. It is shown that sharp changes of physico-chemical properties of the solution take place when both temperature or ionic strength reach critical values. Such changes are discussed in terms of structural variations of the ACTH molecule.