The inhibition of transport of glucose into human erythrocytes by 2,3,4,6-tetra[O-acethyl]-β-d-glucopyranose

L. Lacko, M. Burger
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引用次数: 0

Abstract

2,3,4,6-tetra[O-acetyl]-β-d-glucopyranose penetrated into human erythrocytes following a transport mechanism different from that of glucose. However, TAG interacted with the glucose-carrier ssytem, inhibiting the transport of glucose to a variable extent, depending on experimental conditions.

Comparison of the inhibitory effect of TAG on exchange and non-exchange transport showed that it affected a suppression of glucose transport similar to that obtained by lowering the temperature.

The presence of subtances in the matrix of the membrane which regulate the movement of carriers, interacting similarly to TAG, is tentatively suggested.

2,3,4,6-四[o -乙基]-β-d-葡萄糖吡喃糖对葡萄糖转运到人红细胞的抑制作用
2,3,4,6-四[o -乙酰基]-β-d-葡萄糖通过不同于葡萄糖的转运机制进入人红细胞。然而,TAG与葡萄糖载体系统相互作用,根据实验条件不同,在不同程度上抑制葡萄糖的运输。比较TAG对交换转运和非交换转运的抑制作用表明,TAG对葡萄糖转运的抑制作用类似于降低温度所获得的抑制作用。初步认为,膜基质中存在与TAG类似的调节载体运动的物质。
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