The utilization of 1- and 2-monoglycerides for intestinal triglceride biosynthesis

Abstract

• 1.

  1. Evidence for the intact utilization of 2-monopalmitin for triglyceride biosynthesis by the intestine has been obtained.

• 2.

  2. The enzymes catalyzing the conversion of both the 1- and 2-monoglycerides to triglycerides reside primarily in the microsomes.

• 3.

  3. One enzyme, monoglyceride trasacylase (acyl-CoA:monoglycerides acyltransferase), accepts both the 1- and 2-isomers.

• 4.

  4. The enzyme demonstrates a preferential utilization of the 2-monoglyceride.

• 5.

  5. The interrelationships of the reported finding to the absorption of fats is presented.