Correlation between human colon cancer specific antigens and Raman spectra. Attempting to use Raman spectroscopy in the determination of tumor markers for colon cancer

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-02-01 DOI:10.1016/j.nano.2023.102657

Joanna Depciuch PhD , Paweł Jakubczyk Prof. , Wiesław Paja PhD , Krzysztof Pancerz PhD , Agnieszka Wosiak Prof. , Monika Kula-Maximenko PhD , İlhan Yaylım Prof. , Güldal İnal Gültekin Prof. , Nevzat Tarhan Prof. , Mehmet Tolgahan Hakan PhD , Dilara Sönmez M.Sc , Devrim Sarıbal Prof. , Soykan Arıkan Prof. , Zozan Guleken Prof.

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引用次数: 1

Abstract

Colorectal cancer is the second most common cause of cancer-related deaths worldwide. To follow up on the progression of the disease, tumor markers are commonly used. Here, we report serum analysis based on Raman spectroscopy to provide a rapid cancer diagnosis with tumor markers and two new cell adhesion molecules measured using the ELİSA method. Raman spectra showed higher Raman intensities at 1447 cm⁻¹ 1560 cm⁻¹, 1665 cm^-1, and 1769 cm⁻¹, which originated from CH₂ proteins and lipids, amide II and amide I, and CO lipids vibrations. Furthermore, the correlation test showed, that only the CEA colon cancer marker correlated with the Raman spectra. Importantly, machine learning methods showed, that the accuracy of the Raman method in the detection of colon cancer was around 95 %. Obtained results suggest, that Raman shifts at 1302 cm⁻¹ and 1306 cm⁻¹ can be used as spectroscopy markers of colon cancer.

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结肠癌特异性抗原与拉曼光谱的相关性研究。尝试用拉曼光谱法测定结肠癌肿瘤标志物

结直肠癌是全球癌症相关死亡的第二大常见原因。为了跟踪疾病的进展，通常使用肿瘤标志物。在这里，我们报告了基于拉曼光谱的血清分析，通过肿瘤标志物和使用ELİSA方法测量的两种新的细胞粘附分子提供快速的癌症诊断。拉曼光谱在1447 cm−1、1560 cm−1、1665 cm−1和1769 cm−1处显示出较高的拉曼强度，这是由CH2蛋白和脂质、酰胺II和酰胺I以及CO脂质振动引起的。此外，相关性检验显示，只有CEA结肠癌标志物与拉曼光谱相关。重要的是，机器学习方法表明，拉曼方法检测结肠癌的准确率约为95%。结果表明，在1302 cm−1和1306 cm−1处的拉曼位移可以作为结肠癌的光谱标记。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.