Xueluer Mu , Yang Liu , Shengsen Liu , Yilin Sun , Nana Lu , Yingxi Lu , Weiqi Li , Xianfeng Zhou , Bin Liu , Zhibo Li
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引用次数: 29
Abstract
We developed a new cyanine-derived near-infrared (NIR) molecular rotor Mu1, which is superior to the traditional cyanines with high viscosity response, large Stokes shift (˜100 nm), and high photo-stability to detect the microscopic viscosity ratiometrically. The time-dependent density functional theory calculations highlighted the structure-optical properties of Mu1 as molecular rotor. Due to the mitochondria-actived fluorescence characteristics, Mu1 was used to track mitochondrial viscosity changes in live cells with high spatial and temporal resolution. This new type of NIR molecular rotor presented herein may open up new opportunities of NIR sensors for biomedical diagnosis and imaging applications.
期刊介绍：
Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.
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