Parabolic bursting induced by veratridine in rat injured sciatic nerves.

Abstract

A specific bursting, parabolic bursting induced by veratridine, has been observed in rat injured sciatic nerve. With the help of Plant model, the biophysical mechanism for such a phenomenon is revealed from the viewpoint of nonlinear dynamical theory. The slow sodium influx educed by veratridine and the calcium-dependent potassium outflux are regarded as the two slow variables, which are responsible for the parabolic bursting. Furthermore, the roles that veratridine plays in the emergence of the parabolic bursting, namely inhibiting the inactivation of sodium channels and eliciting the slow sodium influx, are clarified.