Phospholipase A(2).

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-08-01 DOI:10.1016/s0952-3278(03)00069-3

Bruno L Diaz, Jonathan P Arm

引用次数: 174

Abstract

Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA(2) enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation.

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磷脂酶(2)。

在表征个体参与酶及其在生成类二十烷、花生四烯酸衍生的脂质介质(如前列腺素和白三烯)中的相对贡献方面取得了相当大的进展。然而，在生物过程中，单个磷脂酶(PL) A(2)酶向下游酶提供花生四烯酸以生成类二十烷酸的作用尚未完全阐明。在这篇综述中，我们将概述PLA(2)酶家族的分类，它们可能的作用机制，以及它们在类二十烷生成和炎症中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.