A novel PGD(2) receptor expressed in eosinophils.

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-08-01 DOI:10.1016/s0952-3278(03)00079-6

William S Powell

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引用次数: 25

Abstract

PGD(2) is a major product of arachidonic acid metabolism by mast cells and is released in the lungs following allergen challenge. Activation of the classic PGD(2) receptor (DP receptor) results in stimulation of adenylyl cyclase, resulting in inhibition of platelet aggregation and smooth muscle relaxation. A second PGD(2) receptor has recently been identified and designated as the DP(2) receptor, or chemoattractant receptor-homologous molecule expressed on Th2 cells. PGD(2) acts through the DP(2) receptor to induce eosinophil chemotaxis, actin polymerization, calcium mobilization, and adhesion molecule expression. The most potent DP(2) receptor agonist yet identified is 15R-methyl-PGD(2), which has the unnatural R configuration at C(15). 15-Deoxy-Delta(12,14)-PGJ(2) is also a potent DP(2) receptor agonist that activates eosinophils at concentrations much lower than those required for its anti-inflammatory effects. Because of its critical location in the lung and its potent effects on eosinophils, PGD(2) may be an important proinflammatory mediator in asthma.

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一种在嗜酸性粒细胞中表达的新型PGD(2)受体。

PGD(2)是肥大细胞花生四烯酸代谢的主要产物，在过敏原攻击后在肺部释放。经典PGD(2)受体(DP受体)的激活导致腺苷酸环化酶的刺激，从而抑制血小板聚集和平滑肌松弛。第二种PGD(2)受体最近被鉴定并指定为DP(2)受体，或化学引诱剂受体同源分子在Th2细胞上表达。PGD(2)通过DP(2)受体诱导嗜酸性粒细胞趋化、肌动蛋白聚合、钙动员和粘附分子表达。目前发现的最有效的DP(2)受体激动剂是15r -甲基- pgd(2)，它在C(15)处具有非自然的R构型。15-脱氧- δ (12,14)-PGJ(2)也是一种有效的DP(2)受体激动剂，其激活嗜酸性粒细胞的浓度远低于其抗炎作用所需的浓度。由于PGD在肺中的关键位置及其对嗜酸性粒细胞的强大作用，PGD(2)可能是哮喘中重要的促炎介质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.