PhD Luis M. Montuenga (Professor), PhD Laura Guembe, PhD M. Angela Burrell, PhD M. Elena Bodegas, PhD Alfonso Calvo, MD PhD Jesús J. Sola, PhD Pilar Sesma (Professor), PhD Ana C. Villaro (Professor)
{"title":"The diffuse endocrine system: from embryogenesis to carcinogenesis","authors":"PhD Luis M. Montuenga (Professor), PhD Laura Guembe, PhD M. Angela Burrell, PhD M. Elena Bodegas, PhD Alfonso Calvo, MD PhD Jesús J. Sola, PhD Pilar Sesma (Professor), PhD Ana C. Villaro (Professor)","doi":"10.1016/S0079-6336(03)80004-9","DOIUrl":null,"url":null,"abstract":"<div><p>In the present review we will summarise the current knowledge about the cells comprising the Diffuse Endocrine System (DES) in mammalian organs. We will describe the morphological, histochemical and functional traits of these cells in three major systems gastrointestinal, respiratory and prostatic. We will also focus on some aspects of their ontogeny and differentiation, as well as to their relevance in carcinogenesis, especially in neuroendocrine tumors. The first chapter describes the characteristics of DES cells and some of their specific biological and biochemical traits. The second chapter deals with DES in the gastrointestinal organs, with special reference to the new data on the differentiation mechanisms that leads to the appearance of endocrine cells from an undifferentiated stem cell. The third chapter is devoted to DES of the respiratory system and some aspects of its biological role, both, during development and adulthood. Neuroendocrine hyperplasia and neuroendocrine lung tumors are also addressed. Finally, the last chapter deals with the prostatic DES, discussing its probable functional role and its relevance in hormone-resistant prostatic carcinomas.</p></div>","PeriodicalId":54550,"journal":{"name":"Progress in Histochemistry and Cytochemistry","volume":"38 2","pages":"Pages 153-272"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0079-6336(03)80004-9","citationCount":"49","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Histochemistry and Cytochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079633603800049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 49
Abstract
In the present review we will summarise the current knowledge about the cells comprising the Diffuse Endocrine System (DES) in mammalian organs. We will describe the morphological, histochemical and functional traits of these cells in three major systems gastrointestinal, respiratory and prostatic. We will also focus on some aspects of their ontogeny and differentiation, as well as to their relevance in carcinogenesis, especially in neuroendocrine tumors. The first chapter describes the characteristics of DES cells and some of their specific biological and biochemical traits. The second chapter deals with DES in the gastrointestinal organs, with special reference to the new data on the differentiation mechanisms that leads to the appearance of endocrine cells from an undifferentiated stem cell. The third chapter is devoted to DES of the respiratory system and some aspects of its biological role, both, during development and adulthood. Neuroendocrine hyperplasia and neuroendocrine lung tumors are also addressed. Finally, the last chapter deals with the prostatic DES, discussing its probable functional role and its relevance in hormone-resistant prostatic carcinomas.
期刊介绍:
Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.