Male Genital Tract Inflammation: The Role of Selected Interleukins in Regulation of Pro-Oxidant and Antioxidant Enzymatic Substances in Seminal Plasma

Dorota Sanocka, Piotr Jędrzejczak, Anna Szumała-Kaękol, Monika Frączek, Maciej Kurpisz
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引用次数: 120

Abstract

ABSTRACT: Human semen contains spermatozoa as well as populations of round nonspermatozoal cells primarily consisting of leukocytes. Activation of white blood cells present in the seminal plasma during genital tract inflammation and cellular reactions against microbial agents may provoke a release of a variety of products such as cytokines and reactive oxygen species. The aim of this study was to evaluate whether a panel of selected cytokines (interleukin [IL]-1β, IL-6, IL-8, and tumor necrosis factor-α [TNFα]) detectable in seminal plasma during male genital tract inflammation could be considered as mediators between altered semen parameters and changed levels of pro-oxidant and antioxidant substances. Studies using chemiluminometric, spectrophotometric, and enzyme-linked immunosorbent assay methods indicate that proinflammatory cytokines such as IL-1β, IL-6, IL-8, and TNFα may modulate pro-oxidant and antioxidant activities in the male genital tract. The data also suggest that the function of pro-oxidant and antioxidant systems in semen may directly influence basic semen parameters. The elevated numbers of leukocytes present in semen during male genital tract inflammation without an associated contribution of cytokines and semen antioxidant capacity appear to be of little prognostic value in evaluating male fertilization potential.

Abstract Image

男性生殖道炎症:选定的白细胞介素在精浆中促氧化和抗氧化酶物质调节中的作用
摘要:人精液中含有精子和主要由白细胞组成的圆形非精子细胞群。在生殖道炎症和细胞对抗微生物剂的反应过程中,存在于精浆中的白细胞被激活,可能引发多种产物的释放,如细胞因子和活性氧。本研究的目的是评估在男性生殖道炎症期间精浆中检测到的一组选定的细胞因子(白细胞介素[IL]-1β, IL-6, IL-8和肿瘤坏死因子-α [TNFα])是否可以被认为是精液参数改变和促氧化剂和抗氧化剂水平改变之间的介质。化学发光法、分光光度法和酶联免疫吸附法的研究表明,促炎细胞因子如IL-1β、IL-6、IL-8和TNFα可能调节男性生殖道的促氧化和抗氧化活性。这些数据还表明,精液中促氧化和抗氧化系统的功能可能直接影响精液的基本参数。在男性生殖道炎症期间,精液中存在的白细胞数量升高,而没有细胞因子和精液抗氧化能力的相关贡献,在评估男性受精潜力方面似乎没有什么预后价值。
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来源期刊
Journal of andrology
Journal of andrology 医学-男科学
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5.6 months
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