Participation of muscarinic acetylcholine receptors in nitric oxide pathway in cat duodenum.

L I Shikova, N I Kortezova
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Abstract

The effect of activation of muscarinic acetylcholine subtype M1 receptors on the electrical field stimulation (EFS)-induced contractions in cat duodenal muscle strips was investigated. EFS elicited two types of responses: a) on-contraction; and b) off-contraction. The EFS-evoked responses were tetrodotoxin- and atropine-sensitive. In all strips the muscarinic acetylcholine subtype M1 agonist (4-Hydroxy-2-butynyl)-1-trimethylammonium-m-chlorocarbanilate chloride (McN-A-343) increased the tone and the amplitude of the spontaneous contractions. On this background EFS produced an inhibition of the phasic contractions at switching on the stimulation, followed by off-contractions. The EFS-induced inhibition was removed by N omega-nitro-L-arginine and was partly overcome by L-arginine. The results suggest the participation of muscarinic acetylcholine subtipe M1 receptors in the mediation of nitrergic inhibitory responses in cat duodenum.

毒蕈碱类乙酰胆碱受体在猫十二指肠一氧化氮通路中的参与。
研究了毒蕈碱型乙酰胆碱M1受体的激活对电场刺激引起的猫十二指肠肌条收缩的影响。电刺激引起两种类型的反应:a)收缩;b)停止收缩。efs诱发的反应对河豚毒素和阿托品敏感。在所有条带中,毒蕈碱乙酰胆碱亚型M1激动剂(4-羟基-2-丁基)-1-三甲基铵-m-氯氨基甲酸盐(McN-A-343)增加了自发收缩的张力和幅度。在此背景下,EFS在打开刺激时产生了对阶段性收缩的抑制,随后是关闭收缩。efs诱导的抑制作用被N - ω -硝基- l -精氨酸去除,部分被l -精氨酸克服。结果提示毒蕈碱类乙酰胆碱亚型M1受体参与了猫十二指肠氮能抑制反应的介导。
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