{"title":"The effects of peptide and nonpeptide angiotensin II-receptor ligands on the activity of brain monoamine oxidase in water-repleted rats.","authors":"S Stancheva, L Alova, V Georgiev","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effects of i.c.v. administered peptide and nonpeptide ANG II-receptor ligands (losartan, EXP 3174, saralasin and sarmesin) on monoamine oxidase A (MAO-A) and MAO-B activities in the frontal cortex, striatum, hypothalamus and hippocampus of water-repleted rats were investigated. Alterations in MAO-A and MAO-B activities were found in different rat brain regions after ANG II which depended on the isoenzyme type and brain structure. MAO-A activity significantly increased in the frontal cortex and hypothalamus, brain regions containing AT1 receptors, mainly. MAO-A and MAO-B activities were affected differently by all studied ANG II-receptor ligands, which in most cases antagonized the effect of ANG II (losartan, an AT1-nonpeptide receptor antagonist being the most effective). There was no clearcut relationship between the inhibition of ANG II-induced water intake and the changes of MAO-A and MAO-B activities under the effect of the ANG II-receptor antagonists studied.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica et pharmacologica Bulgarica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The effects of i.c.v. administered peptide and nonpeptide ANG II-receptor ligands (losartan, EXP 3174, saralasin and sarmesin) on monoamine oxidase A (MAO-A) and MAO-B activities in the frontal cortex, striatum, hypothalamus and hippocampus of water-repleted rats were investigated. Alterations in MAO-A and MAO-B activities were found in different rat brain regions after ANG II which depended on the isoenzyme type and brain structure. MAO-A activity significantly increased in the frontal cortex and hypothalamus, brain regions containing AT1 receptors, mainly. MAO-A and MAO-B activities were affected differently by all studied ANG II-receptor ligands, which in most cases antagonized the effect of ANG II (losartan, an AT1-nonpeptide receptor antagonist being the most effective). There was no clearcut relationship between the inhibition of ANG II-induced water intake and the changes of MAO-A and MAO-B activities under the effect of the ANG II-receptor antagonists studied.
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