Running wheel size influences circadian rhythm period and its phase shift in mice.

T Deboer, I Tobler
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引用次数: 37

Abstract

Running wheels are widely used in studies on biological rhythms. In mice wheel diameters have ranged from 11 cm to 23 cm. We provided mice with running wheels of two different sizes: 15 cm diameter and 11 cm diameter. The amount of running in the 12-h light:12-h dark condition and the endogenous period of wheel running in constant darkness was determined over 40 days. On the 1st day in constant darkness all animals were exposed to a 15-min light pulse at circadian time 13. The animals in the small wheel ran significantly less both in 12 h light: 12 h dark and constant darkness, and showed a longer endogenous period in constant darkness compared to animals in the large wheel. Moreover, after the light pulse at circadian time 13, mice in the small wheel showed a significantly smaller phase delay in running wheel activity than mice in the larger wheels. The data suggest that the magnitude of a photic phase shift depends on the amount and timing of activity the animals display in relation to this stimulus. It can be concluded that technical features of the running wheel can influence the circadian period of wheel running.

跑步轮大小影响小鼠昼夜节律周期及其相移。
滚轮在生物节律研究中有着广泛的应用。小鼠的车轮直径从11厘米到23厘米不等。我们给小鼠提供了直径15厘米和11厘米两种不同尺寸的跑步轮。在40 d内测定12 h光照条件下的跑量、12 h黑暗条件下的跑量和恒暗条件下车轮内源跑期。在持续黑暗的第1天,所有动物在昼夜节律时间13暴露在15分钟的光脉冲下。小轮组动物在12小时光照、12小时黑暗和持续黑暗条件下的跑步量均显著减少,且在持续黑暗条件下的内源性周期较大轮组动物长。此外,在昼夜节律时间13的光脉冲后,小轮组的小鼠在跑轮活动中的相位延迟明显小于大轮组的小鼠。数据表明,光相移的大小取决于动物在这种刺激下表现出的活动的数量和时间。由此可见,跑轮的技术特性会影响跑轮的昼夜节律。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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