{"title":"The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function","authors":"Lewis L Lanier, Alexander B.H Bakker","doi":"10.1016/S0167-5699(00)01745-X","DOIUrl":null,"url":null,"abstract":"<div><p>DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12<sup>−/−</sup>) show normal development of hematopoietic cells. However, DAP12<sup>−/−</sup> humans develop presenile dementia and bone cysts, and DAP12<sup>−/−</sup> mice show impaired immune responses<em>.</em></p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 611-614"},"PeriodicalIF":0.0000,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01745-X","citationCount":"215","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016756990001745X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 215
Abstract
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12−/−) show normal development of hematopoietic cells. However, DAP12−/− humans develop presenile dementia and bone cysts, and DAP12−/− mice show impaired immune responses.
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