{"title":"Type I interferons and T helper development","authors":"J.David Farrar, Kenneth M Murphy","doi":"10.1016/S0167-5699(00)01710-2","DOIUrl":null,"url":null,"abstract":"<div><p><span>Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4</span><sup>+</sup> T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4<sup>+</sup> T cells to undergo IFN-1-induced Stat4 activation and Th1 development.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 484-489"},"PeriodicalIF":0.0000,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01710-2","citationCount":"112","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900017102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 112
Abstract
Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.
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