Adsorption and self-assembly of bio-organic molecules at model surfaces: A route towards increased complexity

IF 8.2 1区 化学 Q1 CHEMISTRY, PHYSICAL
Dominique Costa , Claire-Marie Pradier , Frederik Tielens , Letizia Savio
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引用次数: 59

Abstract

Understanding the bio-physical–chemical interactions at nanostructured biointerfaces and the assembly mechanisms of so-called hybrid nano-composites is nowadays a key issue for nanoscience in view of the many possible applications foreseen.

The contribution of surface science in this field is noteworthy since, using a bottom-up approach, it allows the investigation of the fundamental processes at the basis of complex interfacial phenomena and thus it helps to unravel the elementary mechanisms governing them.

Nowadays it is well demonstrated that a wide variety of different molecular assemblies can form upon adsorption of small biomolecules at surfaces. The geometry of such self-organized structures can often be tuned by a careful control of the experimental conditions during the deposition process. Indeed an impressive number of studies exists (both experimental and – to a lesser extent – theoretical), which demonstrates the ability of molecular self-assembly to create different structural motifs in a more or less predictable manner, by tuning the molecular building blocks as well as the metallic substrate.

In this frame, amino acids and small peptides at surfaces are key, basic, systems to be studied. The amino acids structure is simple enough to serve as a model for the chemisorption of biofunctional molecules, but their adsorption at surfaces has applications in surface functionalization, in enantiospecific catalysis, biosensing, shape control of nanoparticles or in emerging fields such as “green” corrosion inhibition.

In this paper we review the most recent advances in this field. We shall start from the adsorption of amino acids at metal surfaces and we will evolve then in the direction of more complex systems, in the light of the latest improvements of surface science techniques and of computational methods. On one side, we will focus on amino acids adsorption at oxide surfaces, on the other on peptide adsorption both at metal and oxide substrates. Particular attention will be drawn to the added value provided by the combination of several experimental surface science techniques and to the precious contribution of advanced complementary computational methods to resolve the details of systems of increased complexity. Finally, some hints on experiments performed in presence of water and then characterized in UHV and on the related theoretical work will be presented. This is a further step towards a better approximation of real biological systems. However, since the methods employed are often not typical of surface science, this topic is not developed in detail.

生物有机分子在模型表面的吸附和自组装:增加复杂性的途径
考虑到许多可能的应用前景,理解纳米结构生物界面上的生物物理化学相互作用和所谓的混合纳米复合材料的组装机制是当今纳米科学的一个关键问题。表面科学在这一领域的贡献是值得注意的,因为使用自下而上的方法,它允许在复杂界面现象的基础上研究基本过程,从而有助于揭示控制它们的基本机制。现在已经很好地证明了小生物分子在表面吸附后可以形成各种不同的分子组合。这种自组织结构的几何形状通常可以通过在沉积过程中仔细控制实验条件来调整。事实上,大量的研究(既有实验研究,也有较少的理论研究)证明了分子自组装的能力,通过调整分子构建块和金属基底,以或多或少可预测的方式创造出不同的结构基序。在这个框架中,氨基酸和表面的小肽是关键的,基本的,需要研究的系统。氨基酸结构简单,足以作为生物功能分子化学吸附的模型,但它们在表面的吸附在表面功能化,对映体特异性催化,生物传感,纳米颗粒的形状控制或新兴领域,如“绿色”腐蚀抑制中有应用。本文综述了该领域的最新进展。我们将从氨基酸在金属表面的吸附开始,根据表面科学技术和计算方法的最新改进,我们将朝着更复杂系统的方向发展。一方面,我们将专注于氨基酸在氧化物表面的吸附,另一方面是肽在金属和氧化物底物上的吸附。将特别注意几种实验表面科学技术的结合所提供的附加价值,以及先进的互补计算方法对解决日益复杂的系统细节的宝贵贡献。最后,对在有水的情况下进行实验,然后在特高压下进行表征以及相关的理论工作提出了一些提示。这是朝着更好地近似真实生物系统又迈进了一步。然而,由于所采用的方法往往不是典型的表面科学,这个主题没有详细发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Surface Science Reports
Surface Science Reports 化学-物理:凝聚态物理
CiteScore
15.90
自引率
2.00%
发文量
9
审稿时长
178 days
期刊介绍: Surface Science Reports is a journal that specializes in invited review papers on experimental and theoretical studies in the physics, chemistry, and pioneering applications of surfaces, interfaces, and nanostructures. The topics covered in the journal aim to contribute to a better understanding of the fundamental phenomena that occur on surfaces and interfaces, as well as the application of this knowledge to the development of materials, processes, and devices. In this journal, the term "surfaces" encompasses all interfaces between solids, liquids, polymers, biomaterials, nanostructures, soft matter, gases, and vacuum. Additionally, the journal includes reviews of experimental techniques and methods used to characterize surfaces and surface processes, such as those based on the interactions of photons, electrons, and ions with surfaces.
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