Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51.

M A Sims, S D Field, M R Barnes, N Shaikh, K Ellington, K E Murphy, N Spurr, D A Campbell
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引用次数: 18

Abstract

The integrin family of receptors serves as major receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organisation, cell proliferation, survival, and differentiation. The alpha-V integrins consist of a subset which share a common alpha-V subunit combined with one of five beta subunits (beta-1, 3, 5, 6, or 8). The alpha-V integrins have been implicated in a number of developmental processes, including vasculogenesis and angiogenesis, and are therapeutic targets for inhibition of angiogenesis and osteoporosis. The human cDNA for alpha-V integrin (ITGAV) consists of a 5,717-bp transcript with a coding sequence (CDS) of 3,146 bp encoding a 150-kDa mature peptide. Here we describe the gene structure of ITGAV.

人细胞粘附蛋白(玻璃体粘连蛋白)受体α亚基CD51基因组序列的克隆与鉴定。
整合素受体家族是细胞外基质介导的细胞粘附和迁移、细胞骨架组织、细胞增殖、存活和分化的主要受体。α - v整合素由一个亚群组成,该亚群与五种β亚基(β -1、3、5、6或8)中的一种具有共同的α - v亚基。α - v整合素与许多发育过程有关,包括血管生成和血管生成,并且是抑制血管生成和骨质疏松症的治疗靶点。人α - v整合素(ITGAV) cDNA由5717 bp的转录本和3146 bp的编码序列组成,编码150 kda的成熟肽。本文描述了ITGAV的基因结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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