Sertraline inhibits the contractile responses to noradrenaline, KCI and electrical field stimulation of rat isolated vas deferens

Autonomic and Autacoid Pharmacology Pub Date : 2009-01-09 DOI:10.1111/j.1365-2680.1999.tb00010.x

N. I. Kalyoncu, R. Ozyavuz, S. Karaoglu

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引用次数: 28

Abstract

1 The aim of this study was to investigate the effect of sertraline, a selective serotonin re-uptake inhibitor, on contractile responses to noradrenaline (NA), KCI, serotonin (5-HT) and electrical field stimulation of rat isolated vas deferens.

2 Pre-treatment with 10^-4 M sertraline showed inhibitory effects on responses to NA, KCI, 5-HT and electrical field stimulation, while pre-treatment with 10 ^-6 and 10^-5 M sertraline caused potentiation of responses to NA (10^-7 and 10^-6 M).

3 A voltage-dependent calcium channel activator, Bay K 8644, restored the inhibited responses when sertraline was washed out of the organ bath, although restoration could not be seen when sertraline was not removed.

4 The inhibition of the contractile responses by sertraline pre-treatment may be via a mechanism through calcium channels which is additional to the selective serotonin re-uptake inhibitory effect of sertraline.

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舍曲林抑制大鼠离体输精管对去甲肾上腺素、KCI和电场刺激的收缩反应

本研究的目的是研究舍曲林(一种选择性5-羟色胺再摄取抑制剂)对大鼠离体输精管对去甲肾上腺素(NA)、KCI、5-羟色胺(5-HT)和电场刺激的收缩反应的影响。2、10-4 M舍曲林预处理对NA、KCI、5-HT和电场刺激的反应有抑制作用，10-6 M和10-5 M舍曲林预处理对NA(10-7和10-6 M)的反应有增强作用。3、电压依赖性钙通道激活剂Bay K 8644在舍曲林被洗出器官浴时恢复了被抑制的反应，但在不去除舍曲林时没有恢复。4舍曲林预处理对收缩反应的抑制可能是通过钙通道的机制，这是舍曲林选择性5 -羟色胺再摄取抑制作用的补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Autonomic and Autacoid Pharmacology

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