Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue.

Journal of Experimental Zoology Pub Date : 2000-08-15
E L Jockusch, K A Ober
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引用次数: 0

Abstract

Wnt genes encode a conserved family of secreted signaling proteins that play many roles in arthropod and vertebrate development. We have investigated both the phylogenetic history and molecular evolution of this gene family. We have identified a novel Wnt gene in a diversity of arthropods that it is likely an orthologue of the vertebrate Wnt-10 group. Wnt-10 is one of only two cases in which orthology between protostome and deuterostome genes could be consistently assigned based on our analyses. Despite difficulties in assessing orthologies, all of our trees suggest that the most recent common ancestor of protostomes and deuterostomes possessed more than the five Wnt genes known from either arthropods or nematodes. This suggests that Wnt gene loss has occurred during protostome evolution. In addition, we examined the rate of amino acid evolution in the two arthropod/deuterostome orthology groups we identified. We found little rate variation across taxa, with the exception that Drosophila Wnt-1 is evolving more rapidly than all vertebrate and most arthropod orthologues.

Wnt基因家族的系统发育分析及节肢动物Wnt -10同源物的发现。
Wnt基因编码一个保守的分泌信号蛋白家族,在节肢动物和脊椎动物的发育中发挥许多作用。我们研究了该基因家族的系统发育史和分子进化。我们已经在多种节肢动物中发现了一种新的Wnt基因,它可能是脊椎动物Wnt-10群的同源物。根据我们的分析,Wnt-10是原口动物和后口动物基因之间的同源性可以一致分配的仅有的两个案例之一。尽管在评估同源性方面存在困难,但我们所有的树都表明,原口动物和后口动物最近的共同祖先拥有超过5个已知的节肢动物或线虫的Wnt基因。这表明Wnt基因丢失发生在原细胞进化过程中。此外,我们还研究了我们确定的两个节肢动物/后口动物类群的氨基酸进化速率。除了果蝇Wnt-1的进化速度比所有脊椎动物和大多数节肢动物的进化速度都要快之外,我们发现不同分类群的进化速度几乎没有变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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