Identification and mapping of swine cyclin-dependent kinase inhibitor CDKN2A and CDKN2B exon 2 sequences.

C Le Chalony, H Hayes, G Frelat, C Geffrotin
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引用次数: 5

Abstract

We have isolated the swine homologs of human CDKN2A and CDKN2B exon 2 sequences. As in the human and mouse genomes, the exon 2 sequences of these two genes present a high level of sequence homology and are tightly linked. Using fluorescence in situ hybridization, we have mapped swine CDKN2A and CDKN2B to chromosome 1q25. This confirms the comparative mapping data among man, mouse, and swine, showing a conserved synteny among chromosome segments 9p21, 4C3-C6, and 1q25, respectively.

猪周期蛋白依赖性激酶抑制剂CDKN2A和CDKN2B外显子2序列的鉴定和定位。
我们分离出了人类CDKN2A和CDKN2B外显子2序列的猪同源物。与人类和小鼠基因组一样,这两个基因的外显子2序列具有高度的序列同源性,并且紧密相连。利用荧光原位杂交技术,我们将猪CDKN2A和CDKN2B定位到染色体1q25上。这证实了人类、小鼠和猪之间的比较图谱数据,显示染色体片段9p21、4C3-C6和1q25之间分别具有保守的同质性。
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