Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization.

E S Tasheva, M Pettenati, C Von Kap-Her, G W Conrad
{"title":"Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization.","authors":"E S Tasheva, M Pettenati, C Von Kap-Her, G W Conrad","doi":"10.1159/000015521","DOIUrl":null,"url":null,"abstract":"Mimecan is a small leucine-rich proteoglycan originally isolated in a truncated form as a bone-associated glycoprotein, osteoglycin (Madisen et al., 1990). It was later shown to be a corneal keratan sulfate proteoglycan (KSPG), present in other tissues without keratan sulfate chains (Funderburgh et al., 1997). Along with dermatan sulfate proteoglycans and collagens, KSPGs play a key role in the development and maintenance of corneal transparency. Recently, we isolated genomic clones and determined the genomic organization of the bovine mimecan gene, as well as a partial genomic structure of the human mimecan gene, OGN (Tasheva et al., 1999). By using fluorescence in situ hybridization (FISH), we have assigned OGN to human chromosome band 9q22. Materials and methods","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 3-4","pages":"326-7"},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015521","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytogenetics and cell genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000015521","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15

Abstract

Mimecan is a small leucine-rich proteoglycan originally isolated in a truncated form as a bone-associated glycoprotein, osteoglycin (Madisen et al., 1990). It was later shown to be a corneal keratan sulfate proteoglycan (KSPG), present in other tissues without keratan sulfate chains (Funderburgh et al., 1997). Along with dermatan sulfate proteoglycans and collagens, KSPGs play a key role in the development and maintenance of corneal transparency. Recently, we isolated genomic clones and determined the genomic organization of the bovine mimecan gene, as well as a partial genomic structure of the human mimecan gene, OGN (Tasheva et al., 1999). By using fluorescence in situ hybridization (FISH), we have assigned OGN to human chromosome band 9q22. Materials and methods
mimecan基因(OGN)在人染色体9q22带的原位杂交。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信