The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.

Anti-cancer drug design Pub Date : 1999-10-01

C Cole, A J Foster, S Freeman, M Jaffar, P E Murray, I J Strafford

引用次数: 0

Abstract

The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological rôle of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.

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肿瘤化疗中胸苷磷酸化酶/PD-ECGF的rôle:化学观点。

血管生成生长因子胸苷磷酸化酶/PD-ECGF已被确定为抗癌药物开发的潜在靶点。本文首先综述了TP/PD-ECGF的生物学rôle及其在5-氟尿嘧啶及其前药活化中的重要作用。本文还讨论了TP/PD-ECGF抑制剂的化学和化疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer drug design

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